What characterizes disseminated intravascular coagulation (DIC) in infants?

What characterizes disseminated intravascular coagulation (DIC) in infants?

• A. Acute increase in coagulation factors
• B. Deficiency in coagulation factors and platelets
• C. Independently occurring hemorrhagic disease
• D. Hypotension without associated illness

Answer: (B)

Disseminated intravascular coagulation (DIC) in infants is characterized by a deficiency in coagulation factors and platelets. In DIC, there is an abnormal activation of the coagulation cascade, which leads to widespread clotting in small blood vessels. This increased clotting consumes platelets and clotting factors, resulting in a paradoxical increased risk of bleeding as these components become depleted. Thus, the clinical picture often includes thrombocytopenia (low platelet count) and a deficiency of coagulation factors, which contribute to the hemorrhagic complications commonly associated with DIC. Understanding this deficiency is crucial in managing DIC effectively, as it guides treatment approaches and monitoring in affected infants.

Disseminated intravascular coagulation (DIC) in infants is characterized by a deficiency in coagulation factors and platelets. In DIC, there is an abnormal activation of the coagulation cascade, which leads to widespread clotting in small blood vessels. This increased clotting consumes platelets and clotting factors, resulting in a paradoxical increased risk of bleeding as these components become depleted. Thus, the clinical picture often includes thrombocytopenia (low platelet count) and a deficiency of coagulation factors, which contribute to the hemorrhagic complications commonly associated with DIC. Understanding this deficiency is crucial in managing DIC effectively, as it guides treatment approaches and monitoring in affected infants.